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Indium-111-labeled autologous leukocyte imaging and fecal excretion

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Indium-111-labeled autologous leukocyte imaging and fecal excretion

Auteurs : RBID : ISTEX:10620_1987_Article_BF01296291.pdf

English descriptors

KwdEn :
- Imaging in inflammatory bowel disease, Indium-111, Leukocyte.

Abstract

This study was designed to evaluate the role of111In-labeled leukocyte imaging and fecal excretion in the assessment of inflammatory bowel disease. We compared these tests to various indices of disease activity in Crohn's disease, to Truelove's grading in ulcerative colitis, and to endoscopy, x-ray, and pathology in both diseases. Eleven controls, 16 patients with Crohn's disease, 13 with ulcerative colitis, and 3 with other types of acute bowel inflammation were studied (positive controls). Indium scanning was performed at 1,4, and 24 hr. Fourteen of 16 patients with active Crohn's disease had positive scans but in only five was localization accurate. One patient had inactive ulcerative colitis, and the scan was negative. Of 12 patients with active ulcerative colitis, 10 had positive scans but disease localization was accurate in only four. Disease extent was correctly defined in 1 of the 3 Positive Controls. There was no significant difference in the accuracy of scanning at 1,4 or 24 hr.111In fecal excretion was significantly higher in patients with inflammatory bowel disease than in controls, and there was correlation between111In fecal excretion and most of the indices of disease activity in Crohn's disease. In ulcerative colitis,111In fecal excretion did not correlate with Truelove's grading but reflected colonoscopic assessment of severity. In conclusion,111In-labeled leukocyte scanning lacks sensitivity with respect to disease extent, but fecal excretion of111In correlates well with disease severity as determined by other methods.

DOI: 10.1007/BF01296291

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<author><name>D. J. Leddin</name>
<affiliation wicri:level="1"><mods:affiliation>Department of Medicine, Queen's University, Kingston, Ontario, Canada</mods:affiliation>
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<front><div type="abstract" xml:lang="eng">This study was designed to evaluate the role of111In-labeled leukocyte imaging and fecal excretion in the assessment of inflammatory bowel disease. We compared these tests to various indices of disease activity in Crohn's disease, to Truelove's grading in ulcerative colitis, and to endoscopy, x-ray, and pathology in both diseases. Eleven controls, 16 patients with Crohn's disease, 13 with ulcerative colitis, and 3 with other types of acute bowel inflammation were studied (positive controls). Indium scanning was performed at 1,4, and 24 hr. Fourteen of 16 patients with active Crohn's disease had positive scans but in only five was localization accurate. One patient had inactive ulcerative colitis, and the scan was negative. Of 12 patients with active ulcerative colitis, 10 had positive scans but disease localization was accurate in only four. Disease extent was correctly defined in 1 of the 3 Positive Controls. There was no significant difference in the accuracy of scanning at 1,4 or 24 hr.111In fecal excretion was significantly higher in patients with inflammatory bowel disease than in controls, and there was correlation between111In fecal excretion and most of the indices of disease activity in Crohn's disease. In ulcerative colitis,111In fecal excretion did not correlate with Truelove's grading but reflected colonoscopic assessment of severity. In conclusion,111In-labeled leukocyte scanning lacks sensitivity with respect to disease extent, but fecal excretion of111In correlates well with disease severity as determined by other methods.</div>
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<abstract lang="eng">This study was designed to evaluate the role of111In-labeled leukocyte imaging and fecal excretion in the assessment of inflammatory bowel disease. We compared these tests to various indices of disease activity in Crohn's disease, to Truelove's grading in ulcerative colitis, and to endoscopy, x-ray, and pathology in both diseases. Eleven controls, 16 patients with Crohn's disease, 13 with ulcerative colitis, and 3 with other types of acute bowel inflammation were studied (positive controls). Indium scanning was performed at 1,4, and 24 hr. Fourteen of 16 patients with active Crohn's disease had positive scans but in only five was localization accurate. One patient had inactive ulcerative colitis, and the scan was negative. Of 12 patients with active ulcerative colitis, 10 had positive scans but disease localization was accurate in only four. Disease extent was correctly defined in 1 of the 3 Positive Controls. There was no significant difference in the accuracy of scanning at 1,4 or 24 hr.111In fecal excretion was significantly higher in patients with inflammatory bowel disease than in controls, and there was correlation between111In fecal excretion and most of the indices of disease activity in Crohn's disease. In ulcerative colitis,111In fecal excretion did not correlate with Truelove's grading but reflected colonoscopic assessment of severity. In conclusion,111In-labeled leukocyte scanning lacks sensitivity with respect to disease extent, but fecal excretion of111In correlates well with disease severity as determined by other methods.</abstract>
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<topic>indium-111</topic>
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<titleInfo><title>Digestive Diseases and Sciences</title>
<partNumber>Year: 1987</partNumber>
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<subject usage="primary"><topic>Medicine & Public Health</topic>
<topic>Gastroenterology</topic>
<topic>Hepatology</topic>
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<topic>Transplant Surgery</topic>
<topic>Biochemistry, general</topic>
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Indium-111-labeled autologous leukocyte imaging and fecal excretion

Indium-111-labeled autologous leukocyte imaging and fecal excretion

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri